I don't have Sony Reader Library running (Since it refuses to run properly on my Windows 7 64-bit laptop), so I uninstalled it and use claibre. However, the first time I tried to transfer an ePub drm'd book using ADE, it was unreadable on the PRS600. I had to reinstall the Sony Reader Library, then stop it and not let it start up. It doesn't need to run, but evidently it installs dlls or some other system file that ADE needs to properly recognize an authorized book. So you might not be able to uninstall it and make that work.
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