Smaller screen might make it harder to read the speech bubbles. On the other hand, the DPI is higher (resolution is the same 600x800), so you should get sharper lines. Also note that PRS-300 is missing the picture viewer, so you'll have to convert your comics to PDF, LRF or EPUB (maybe .
Another thing is that PRS-300 is based on the older PRS-505 hardware and so it slower than PRS-600.
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