I love basically everything about Calibre. Whenever I've found a small bug, I've been able to devise a workaround, or it's been fixed on a revision.
One feature I would very much love, as my book collection keeps growing, is to have a full screen cover browse capability--something like what iPad is showing on its iBooks page, and what Mobipocket Reader does. The problem with Mobipocket Reader is that it's very picky about the size of the cover. It has to be just so or it won't show up, or in some cases (in MP Creator) even USE the cover while constructing your ebook.
Calibre, of course, is more robust. The Browse feature works great, but you have to move through a whole library one book at a time. How great would it be to look at a whole section of a bookshelf at one time?
As I try to decide what to read, this would be helpful. Hope it's considered.