It's also possible that some sort of process is running in the background that is keeping the device more active than needed. For example, when you open a file, it loads a separate viewer for that file type: pdf viewer for pdfs, image viewer for images, epub viewer for epubs, and etc. It has been shown that viewing a particular file type for the first time takes longer than subsequent times, which seems to imply that for subsequent use, the viewer is still loaded and ready. This may explain why results are so varied.
I don't know how the device handles task management. That is, when does it shutdown a viewer, if ever? At standby? When switching to another viewer? When a certain resource threshold limit is reached? One way to rule out a runaway or crashed process ruining battery life is to reboot the device before testing and don't do anything with the device. For comparison measurements, it may also help to limit usage to particular features to see if one of them is faulty (example scenario: only view one particular file type and don't turn on 3G").
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