There's no real downside for Apple for their books to not be accessible elsewhere since it helps to lock in their customers, but the lack of support for reading books with adobe drm harms them because it makes people with larger collections less likely to switch if it would mean abandoning all their previous purchases.
While stripping drm is an option for more technical people, it probably isn't something that the majority of people would want to do and you would think that a demographic of fairly non-technical people that buy books regularly would be a useful segment of the market for the iPad.
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