The way conversion works is that at convert time the target screen size is loaded from the users current output profile. That is the screen size that is used. The only reason this is necessary at all is that Adobe Digital Editions stupidly does not rescale images that don't fit on the screen.
So if you want to generate an epub file that has large images and works across a number of devices you have to choose an output profile whose screen size is <= the screen size of the smallest of those devices.
Presumably one of your comic readers suffers from the same limitation as ADE - not rescaling images.
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