When I read .pdb on a Clie, I replaced curly quotes with straight quotes; the curly ones were distracting on a 320 pixel screen. I'm also used to reading a lot of blog/journal entries online, which has almost entirely straight quotes, and fanfic, which should have mostly straight quotes, both because screen resolution can make curly quotes distracting, and some browsers don't display them right and they show up as little question marks instead of quotes. (I gather this is some kind of weird IE compatibility issue. Don't care; am much happier with straight quotes in browser-viewed text.)
I'm just getting to like curly quotes in ebooks, rather than seeing them as a distraction. I use Word, and its autoconvert features, which then need touchup for the exceptions ('Tis '70s 'em —"whatever).
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