Way back when I was reading on a Palm III, the reader I was using choked on curly quotes and other formatting characters. I made it a practice when I was converting books to a readable (for me) format to always change them to a ". It was the opposite of laziness - it actually took an extra step to do (not that find/replace is terribly difficult).
TBH, it doesn't make any difference to me which direction a quotation mark is facing. I know I'm "wrong" from a strict formatting perspective, but it doesn't make an ebook the slightest bit less readable to me. I tend to prefer books to be in the lowest common denominator - plain text, so that I'm able to easily convert them to the several formats in use at my house. Horrifying, I know, to the formatting purists.....
