I've been using a PRS-300 for a little while now but after learning of some of the additional features of the 600 I wanted one. I was especially wanting the ability to expand the storage as well as wanting the touchpad features including hand-writing notes.
As I am stranded in a motel due to an engine break-down in my truck I took a cab to a local mall and picked up the 600 at a Best Buy today, along with a light cover for it.
I've spent the day and evening playing around with it and reading it, and I love it. A simple finger swipe across the screen to turn the page is great, and I can really use the hand-written notes function on the job.
I stuck a 4GB card into the device which greatly increases the storage space. For me that's a great thing as the 300 didn't even come close to storing all of the ebooks I have. With the added storage space the 600 stores them all with ample room to spare.
The ability to play music files while I read is a very big plus for me as I often like to listen to classical music while I read, which is something I miss while reading in a truck stop. Trust me, no Bach playing in the truck stop.
All in all, for a single day of testing, the 600 is a huge winner for me.
Oh, and I already have a buyer for my 300.