For me the medium font works on most books. PDF's can be an issues, some have font's that do not respond to the "zoom" function. If you have books that are DRM free you can convert them in Calibre. One of the great things about converting is that you can control the base font size. So you can output a base 14 font, and all 3 sizes on the 300 will in turn be larger than normal.
I don't know what part of the world you are in (your location is empty) but as I said before the best thing to do is buy one from a local store. Try it to see if eInk and the device are a fit for you. If not, simply return it. Spending some time with one is really the only way to know if it is right for you.
As with most things there is no "best"... there is only what is best for you, and that can be very different than what is best for me, or someone else....
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