I do prefer E-Ink - and jumped from the 500 to the 505 for the slight increase in quality and contrast, and sent back the 700 for a similar slight decrease. I can and do sometimes read on my computer or my iPhone, but find the brightness and glaring contrast to be a limiter before getting sore eyes - though that could be because I'm behind a computer most of the day.
Of course, if I go back 5 years I was happily reading late into the night on my GEB 1150, a back-lit monochrome lcd - in fact my main complaint wasn't eyestrain but insufficient battery life, meaning I must have been reading many hours in a sitting. I don't think my eyes were that much older just 5 years ago. But the GEB1150 did have a nice selection of brightness levels which really helped keep the eyestrain in check.
I would guess that the human eye can adapt to many ways of gathering information. Some might be more idea than others - I'm not sure I could give up E-Ink having grown used to it - but I'm sure each has it's boosters.
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