The Nook and the Kindle have much more in common than they have differences. I have a Nook and have never had any trouble with it with the exception of the "lost place and bookmarks" issue that was resolved last week with the latest firmware update.
I believe that most folks who would love an eReader would be happy with either choice. But take a good look at the differences -- they might be important to you.
For example the Nook reads Epub natively -- the Kindle has far better dictionary support -- the Nook has a replaceable battery and expandable memory -- the Kindle has a hardware keyboard ... and on and on.
The good news is that I don't think you can make a mistake choosing either.
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