For epubs -- I use "S" for for Calibre or Feedbooks-created books, S, M, or L for commercial ebooks (depending on the base font size, which varies). Frequently pop up a size when tired or when the light is low (e.g. on the bus at night).
PDFS on "M" which is the smaller reflow size.
For LRFs, I've found much of the time that even the "S" size is bigger than I prefer.
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