My personal preferences go as follows: my Sony, followed by my Palm TX, followed by my iPaq and then a computer. Form-factor matters more to me than screen technology, at least as far as eyestrain is concerned. One thing that may make a difference with my LCD devices is that I always keep the backlight turned down as low as possible (primarily to extend battery life) so they don't bother my eyes that much.
End result is that I can't read as long on an LCD device as an EPD, but the difference is a matter of degree, not kind.
However, when it comes to devices, I have a very strong preference for ones with an EPD display for reasons other than simple eyestrain. Two big ones are screen size and battery life. I have a 6" Sony, and that's about as small as I am willing to go - I'd prefer larger but I'll settle for 6". EPD battery life is fantastic. I can leave my Sony for a day or two and still have lots of charge left. I can read half a dozen books in a binge session on one charge.
I'd be fine with a decent-size LCD, provided it had what I consider a usable level of battery life. Now usable battery life is a very personal thing, so here's what I consider a minimum: I want to be able to leave the house early in the morning, spend at least 6 hours using it during the day (without access to power) and still have charge left for anywhere from 5 minutes to an hour before going to sleep at night, and ideally not need to charge it until some time the following day. Call it ten hours of active reading and at least 72 hours of standby time.
I can't get that amount of use time on any non-EPD device currently available.
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