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The main problem with viewing PDFs is that they are usually designed for a specific screen size, and provide less-than-satisfactory results when viewed on smaller screens. My experience has been that the entire page will be shrunk to fit on my reader's screen with the result that the text too small to easily read. Although reflow is available, I've been less than satisfied with the results.
I've found that PDF works best for ebooks is if they are formatted for your reader's screen. For me the major advantage of PDF is that it gives you complete control over the layout of your ebooks.
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