Here's the sorting I use with Calibre and in general:
{tags}/{series}/{series_index} {title} - {author}
The only thing I do is edit each book's metadata so the tags only falls under one category and correct the series and series index if needed. For example, if a book falls under Sci-Fi, Fantasy, Fiction, and several other categories, after my edit, the only tag there is Sci-Fi.
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