Blue Nomad annouced the release of BackupBuddy for Windows V2.0, which is a ground-up rewrite of V1.x. I was always a fan of V1.x, so make sure to give this one a try!
BackupBuddy 2 protects all the contents of your handheld by storing, in a database on your PC, all changes made to your device since your last backup. BackupBuddy 2 can restore copies of your programs, data files and settings in the event of any emergency: crashing of your handheld caused by an errant program, an accidental file deletion and damage or theft of your PDA.