I copied this from another thread, sorry, I don't know how to link threads. This will stop the Sony software from starting each time you plug in the reader, I don't know what will happen if you have deleted the software.
"The easiest solution (one I used) is to type msconfig in the "Run" dialog in Windows, and then go to the "Startup" tab and uncheck the box for the Sony Reader software. That should stop the software loading up everytime you plug the reader in. This way, I can load up the software only when I want to. Windows will probably still pop up a prompt asking you what you want to do with the newly detected drive (as it recognizes the memory on the Reader as an external disk). You can disable that by disabling autoplay."
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