I just got back from Barnes and Noble and played with the nook for about 10 minutes.
I found the eink display just as responsive as others. I don't understand the reviewers who said it was not reponsive - it was and the color lcd in fact was a little too sensitive.
I noticed it only had two fonts (I hope you will be able to add more).
The only negative I see is that they should increase the zoom level one more notch. The largest level is fine for most, but I prefer to be able to make the text larger. Hopefully firmware upgrades will add more zoom levels.
It felt good to hold and I had no problem reading Dan Browns the Lost Symbol.
I don't know how Epub or PDF will display, but I like what I've seen