Well I've tested some of these fonts for breve accents, and other glyphs of this kind and they worked.
Some other languages are tricky. For japanese, chinese and korean, we also have to change the font encoding with LaTeX, and we switch to another font too in this case.
100% Unicode fonts would be the best choice, but we'll still get this font encoding problem (can't use T1).
If we can easily embed some of these commercial fonts with PDF files generated on LaTeX, without too many copyright issues, we could buy the extended versions, but I'm afraid that it won't solve much of the problem in this case.
As for the poll... There's no clear winner in the polls yet. Helvetica is leading but with a single vote. On the reader, sans serif fonts seems like the right choice to me but I can also understand why some people would rather have a serif font: we're used to serif fonts in p-books.
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