I like that the 300 is about the same size as a book. The portability isn't an issue for me because almost none of my clothes have pockets anyway, so I almost always have a satchel or other small bag with me, and it's a perfect size for a handbag.
I tend to read for long periods (on weekends I'll happily lie around reading for 10 - 12 hours at a time). I used to read on a Nintendo DS and found my hand would get cramped after just a few hours of holding the smaller device (not to mention the eyestrain from the tiny screen). The 300 is a nice size to hold and read for those long sessions.
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