Wow. I hadn't even thought about what sort of effect the Wacom might have on the system .... I don't know enough about the details of either to make any kind of real evaluation, but the effects could be significant.
On the other hand, that's the sort of thing you'd hope a manufacturer, who
does have all those details (and access to folks who actually
understand them), would take into consideration
before they slap the two pieces together in a big, juicy techno-sandwich.