Thats exactly why I wanted the the PocketBook 360- button placement. It makes it very easy and comfortable to use with either hand. the top button is page forward the lower page back in either left or rigth hand and in landscape the right is page forward and the left is page back.
You can also use the D pad pushing left or right etc. But the best part is the Key mapping feature. If you don't like the default set up you simply switch it to the way you like it. So for left handers holding the bottom like the OP you can switch the page forward to the lower button etc
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