I'm not sure I'm afraid. A bit of a long shot, but do you have other USB ports or PC's you can try running the update app on? No idea why, but when trying to update my 505, the standalone app wouldn't detect my Reader on one laptop, but did on a second one. Different ports (e.g. back rather than front) on a desktop machine have been reported to have the same effect, I think, but no idea why they might.
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