The only problem I, personally run into with the full page preview is that it's hard to get a feel for how big the font is really going to be on the Reader itself. Of course, once you know what size you should set it to for the results you want, that's not a problem you just set and forget.
Otherwise I find the full page preview really nice when I'm generating a book and want a look at the results. I'm glad Sony added it -- it saves a lot of loading to the Reader to check results that I'd otherwise have to do.
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