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There really should not be much difference between 6" EInk screens that don't include a touch screen layer. There is only one source for Vizplex film and only one (or now perhaps two) factories making the screens.
On the other hand the controller and the greyscales might make a bit of a difference, and the PRS-505 has a reputation as a "best of breed" screen. Note that more greyscales are not necessarily better, the Kindle 2's standard font is washed out due to 16-way anti-aliasing.
The Astak EZ Reader Basic is a good alternative to the Sony's. It has a more up to date version of mobile Adobe Digital Editions than all the current Sony devices (although I have not noticed this making much difference for PDFs).
Some devices (Sony's and EZ Reader's) with ADE implement reflow for PDFs and others implment zoom (magnifying part of the page). I have not seen any information on which approach the Nook will use (it could allow both, as does the PRS-600). So if you care about PDFs it would be safest to wait for detailed reviews of the Nook.
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