I usually hold my sony reader prs-600 in my left hand and it is easy for me to press the page turn buttons as they are located just where my left thumb rests - that way I can read one-handed. So sounds like this reader would be a good bet for you on this basis anyhow.
Sometimes I switch to right-handed reading (if I'm on the phone which I hold to my left ear) and very easy to swipe the pages using my right thumb.
The page turns work pretty well I think but I still think I'd prefer a scroll wheel like you get in the middle of a mouse if this could be successfully implemented into the hardware.
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