Sometimes, simplicity wins the day.
PDFRead is an OS-independent application to convert PDF and DJVU documents into various e-book formats with just a few mouse clicks. It is similar to the popular
PDFrasterFarian tool in that it uses several image processing filters to generate highly optimized content for e-book readers.
PDFRead was written by the truly gifted Ashish Kulkarni along with the help from various other MobileRead members including Falstaff, alex_d, and sammykrupa. For an ongoing discussion on PDFRead check out
this thread.