Here is the first of two solutions for VISTA - remember follow the instructions clearly:
http://www.kb.sony.com/selfservice/d...nalId=C1002268
How to authorize the eBook Library software in the Data Prevention Execution feature of the Windows Vista® operating system.
Solution
1. Click the Start button, and then click Control Panel .
2. In the Control Panel window, click System and Maintenance .
3. In the System Maintenance window, click System .
4. In the System window, under Tasks , click Advanced system settings .
5. In the User Account Control window, click the Continue button.
6. In the System Properties window, on the Advanced tab, in the Performance box, click the Settings button.
7. In the Performance Options window, click the Data Execution Prevention tab.
8. On the Data Execution Prevention tab, click the Add... button.
NOTE: If the Add... button is not selectable, Data Execution Prevention is configured for essential Windows programs only and no further changes to Data Execution Prevention are necessary.
9. In the Open window, next to Look in: , click the drop-down arrow and click to select Local Disk (C

.
10. In the selection box, click to select the Program Files folder.
11. In the selection box, click to select the Sony folder.
12. In the selection box, click to select the Reader folder.
13. In the selection box, click to select eBook Library and click the Open button.
14. In the Performance Options window, click to the OK button.