I just use the default 5pt margin setting when converting to EPUB.
LIT's go quite easily. Most of the time nothing else is required other than clicking convert although sometimes I get one that just doesn't look quite right (I'm picky) and I'll edit it a bit in Sigil.
For PDF you'll likely have to go on a case by case basis. Some PDF's convert fairly easily while others are a nightmare. Of course you can read PDF's on the Opus. Never tried it myself and I doubt the results are all that great unless they're formatted for the screen size.
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