Will Calibre reformat DRMed PDFs? I doubt it.

If you bought a reader to read large PDFs, then you probably made the wrong choice. These devices are designed for eBooks using a markup language. They really don't handle bloated PDFs, and they don't handle tables very well in any format, unless the tables were designed for a small screen.

FYI: The Kindle 2 doesn't handle large sized PDFs well either. I doubt any small screen (6" or less) device ever will.