Maximum display size is 768x1024 @ 50Hz, vs 2048 x 1536 @ 50 Hz on the S1D13521. I'm not sure what the Hz rate means for EInk, but the S1D13522 limitation is probably due to its 2MB of built in memory.
The smaller display size still covers 5" to 8" displays, but not the 825 × 1200 9.7" screens and 1024x1280 10+" screens. These can obviously still use the S1D13521.
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