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I've not got any experience with a US reader as I own a UK one, but as I understand it (correct me if I'm wrong) that as long as you register it to the US store and not the UK one, you'll be fine.
You'll be able to purchase books from the US store but not the UK one.
As they are the same hardware it may be possible to register the US reader to the UK store, but I'm not in a possition to check.
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