I definitely think that custom-made PDF looks the best on the reader. The only tool you mentioned for making the PDF, however, is Acrobat, and Acrobat by itself isn't a typesetting system.
My personal preference would be pdfLaTeX (free) for creating the PDF. Depending on your source file format, however, that might be a fair bit of work. You might consider Prince XML (free for personal use) instead for HTML or XML-based source files. Those will give you ligatures, kerning, end of line hyphenation, widow/orphan control. Not sure if they, or any widely available software, will do stacks/river control without hand tweaking. Maybe Scribus (free) or InDesign($$)?
Last edited by frabjous; 09-27-2009 at 01:03 PM.
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