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So far, I have only used my 600 with Vista and have not encountered either of the problems you mentioned. In addition, I have never opened Reader prior to plugging in the device.
All that being said, I really didn't like Reader, so I removed it after a few days and now only use Calibre. It's certainly not a program I would choose to manage my digital library (I've chosen to just go with a file directory cataloging system), but its conversion capabilities have impressed me.
Sorry this isn't much help, but it's at least another data point.
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