At the moment no major format supports animated GIF or fash, so that is concession you'll have to give if you want to go with a popular format.
All the major formats like LIT/MOBI/EPUB are based on HTML so they can pretty much handle all of the formatting issues you have mentioned above.
On last point formats like MOBI and PDF are still much more popular than ePUB, I would not limit the format to just one format but support several formats of the popular formats such as MOBI/LIT/ePUB/PDF.
=X=
Last edited by =X=; 09-26-2009 at 10:34 PM.
Reason: Fixed errors and grammer
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