I havent tried this directly as I don't own a sony reader, but I did spot this and hope it may help some fellow maccers out.
Use Sony Reader on a mac
Quote:
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The Sony Portable Reader -- the PRS500 -- has no official Mac support. But with the help of the libprs500 library, I was able to get a modest but very useful level of functionality without resorting to SD cards.
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Good luck,
micro