I own a Kindle (1st generation) and an iRex DR1000S. I use the Kindle for most of the daily reading - novels, non-fiction books, newspapers, blogs, etc. The only time I use the iRex is for reading PDF files of technical documents and academic publications.
At one point I bought a Kindle DX hoping it will work for both, but it didn't work out. It's a bit large for everyday reading, and not quite enough resolution to read the small text in technical publications. And of course, it doesn't allow handwritten annotations.
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