I find it works intermittently on 10.6.1 with calibre 0.6.11 (normal build) without Rosetta. Will work for a while, then crashes for no apparent reason or at the termination of an add book or conversion job, then usually takes several more attempts to restart it without crashing. Seems no different to me than it did under 10.6.0 with 0.6.11 or 10.6.0 with 0.6.10.