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I think what LDBoblo is complaining about is aliasing, not anti-aliasing. Aliasing is the jagged effect one gets with pixelation, while anti-aliasing refers to techniques to reduce this effect.
I would actually think that PDFs, especially image-based ones, would be worse for aliasing than reflowable formats because the font may not be scaled to the screen resolution, and that would lead to a greater fuzziness in the display.
I know I find the lettering in comics and manga to be fuzzier than standard text-based LRFs and EPUBs.
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