Now that this has gotten started, I will add my own thoughts
1. lets have two versions, the 5" screen version and then maybe an 8" screen version. I would keep the LCD since there is a segment of the market that seems to definitely prefer it to eInk.
2. I would get rid of the left side bar that you can currently use to turn pages. I find it is generally too awkward to use when I am holding it one handed and without it, you could perhaps adapt the left hand side with somesort of handhold.
3. Better PDF support. I don't just want reflow (which after all is only supported if the actual PDF supports it), but also faster page turns. Page turns on regular files are instant, on PDFs they take a second... not usually a big deal, but, hey, this is a wish list
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4. Replaceable battery.
The thought about using a PixelQi screen has occurred to me as well. It would allow for color use.. but is color available without a backlight?
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Bill