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It really depends on what kind of PDF, etc.
If you have a Kindle 1 or Kindle 2 what you're wanting to do is get the PDF into some sort of text format - Word, HTML, etc. After that, you can convert it fairly easily using Calibre, MobiCreator, etc.
I've found that the best software for this is Adobe Acrobat but it's a pretty penny... there are free alternatives of varying quality. So I'd search for PDF to Doc, etc. There's even someone online services that can do it for you.
The problem is that this conversion is rarely pretty, it almost always requires some time editing the text manually to look right, etc.
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