Originally Posted by Steve Jordan
More important than that, I think, is to set your PDF generator to create "tagged" PDFs (in the print options box, check ISO 19005-1 compliant, or PDF/A). Tagged PDFs can reflow on quality non-standard-sized PDF readers, and that often solves the multiple-screen-size issue (3.5x4.5" isn't the only size out there... formatting for that will only serve to tick off those with other screen sizes). Tagged PDFs largely solve the margins issue, because the screen will reflow the text and adjust the margins (or remove them) accordingly.
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