The CyBook Opus is very comfortable to hold and use, and can be used equally well in either hand. It has two large page-turn buttons which (according to which way up you hold the device) can be on either the left or right side. The accelerometer flips the screen (and the function of the buttons) to match whatever orientation you hold the machine in. It's so light (150g) that you can use it one handed very comfortably indeed.
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