My fault, I had to install libusb-dev before running the pyusb setup!
Code:
root@ubuntu:/disk2/sonyreader/libprs500/trunk # prs500 info
Device name: Sony Reader
Device version: PRS-500/U
Software version: 1.0.00.21081
Mime type: application/x-bbeb-book
I am still not able to compile the GUI, but this is already very cool