I think of python 3.0 as a new language. python 3.0 is not backward compatible. Still it's similar enough to 2.x that if you learn 3.0 you should be able to program on 2.x (the biggest change, at least for calibre style programming is the switch to making everything unicode).
As for calibre, I don't foresee migrating it to 3.0 for at least a couple of years more.
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