- Julian Lenz: Jean Reno
- Reya Luis: Penelope Cruz
- Aaron Hardy: Alan Cummings
- Dr. Calvin Rios: Roger Livesey
- Dr. Jacqueline Silver: Audrey Hepburn
- Dr. Valeria Epstein: Daniela Nardini (must remember not to drool....)
- Gaston Lambert: Christopher Lambert, of course!
- Enu Thompson: Dule Hill
- Kris Fawkes: Natalie Portman
- Shay Vaughn: Thandie Newton
- Roy Grand: Laurence Fishburne
- Anise Lenz: Kate Beckinsale
The supporting characters are:
- (hmmm... let me think about some more classic actors, but...)
- “Surprise bad guy”: Either Charles Laughton or Robbie Coltrane.