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I switched to the 505 because of worsening eyesight last year. Some things that I learned from someone here at MR (sorry, forgot who it was) is to increase the line spacing and use sans serif fonts. The goal is to allow for more space to contrast the text and background.
My preference is 1.25 line spacing and ariel font, 22 pt. Although, lately my eyes have gotten better and I can see 20 or even 18 pt font!
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