Paul--Each time you switch cards, the reader will re-create it's index. So, if you have a large amount of books on your cards, it could take awhile to start up after you first put a card in.
That said, I have about 200 books on the internal memory and don't notice my reader being slow at all. I think the slowness people are referring to is what happens when they first start the reader up after changing the contents on it.
dordale