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Exclusivity is less likely in the UK, because many publishers have already standardized on ePub.
In the US there are very few Amazon-specific titles (except TOPAZ, which is a special case since Amazon does the ebook creation), but they are quite a few MOBI+Amazon only titles. This is because producing a mobipocket.com ebook gets you on the Kindle and into most ebook stores. So in the US if you don't want to spend a lot on producing ebooks, or want to do so quickly, the mobipocket.com only approach is viable.
In the UK, some publishers are ePub only but none so far as I know are MOBI only. Amazon can fairly easily convert from ePub to MOBI, although Calibre does this much better than MobiPocket Creator, so ePub is probably OK for them. Given an ePub master, there is no reason for a publisher to be Amazon-only or MOBI-only at the ebook store level.
Given MobiPocket Creator's limitations, I would expect the Kindle ebooks made from an ePub master to have problems when first introduced but Amazon could very simply fix this by allowing Calibre to be used with DRMed MOBIs (i.e. by introducing a program to add DRM to a DRM-free MOBI ebook).
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